Note sure what your budget is, however I stayed here last Friday Night:-
Holborn Grange
It was a part of my Birthday pressie - think it was about £100 inc brekkie for the night, cheapest deal was booking direct with the hotel.
Great location - 1 minute walk from Russell Square tube or Holborn Tube, and about 5 mins or so walk from Covent Garden, Leicester Square, Soho and Oxford Street.
Nice pool and sauna etc. - rooms are pretty big with very comfy beds:-
Also not too far from Islington - looks almost walkable
:-
underground map