Two things eased any hand pain / ache for me. My wrists were always fine but I do carry my weight on my back and stomach muscles at low speeds. Higher speeds and that work is done for me by the wind.
1. Heated grips ( they have a thicker grip)
2. Throttle Buddy - an attachment to the throttle that allows you to be able to open your fingers a bit and use the outside edge of your palm to keep the throttle position.
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