I suffer from Reynaud Syndrome/Vibration White Finger. My 99 naked is sit-up-and-beg and is fine. I've found that the biggest trigger to hand discomfort are the Carbs/Fuel bodies being out-of-sync so I check and do mine as soon as I feel even the slightest vibrations through the bars.
I've even made a page to for it,
http://straticus.epizy.com/SV650CarbBalance.html?i=1